ABSTRACT
Background: Eclampsia, a common medical emergency of pregnancy mainly seen in 5% to 10% of all pregnancies. The objective of the present study was to study the effect of eclampsia on maternal and perinatal outcome.Methods: This cross-sectional study was conducted among 50 clinically diagnosed women with eclampsia in their third trimester of pregnancy. Inclusion criteria for the study was; females with singleton pregnancy, all in the third trimester which were diagnosed to have PIH based on the development of hypertension for the first time, proteinuria with or without edema, with no history of previous urinary tract troubles and no evidence of UTI.Results: Almost 84.0% participants were belonged to age group of 20 to 30 years age, 54.0% were belonged to rural area and 92.0% were belonged to lower socio-economical class, 88.0%% participants were registered as emergency case, 34.0% participants were stayed more than 10 days at hospital and 36.0% were completed ANC visit. Almost 24.0% participants were anemic, 6.0% pre-eclampsic and 4.0% have tween pregnancy. Severe hypertension at the time of admission were noted in 50.0% participants followed by absent knee jerk (12.0%), proteinuria (78.0%) and edema (62.0%) respectively. Maternal mortality and still birth observed in 2.0% and 18.0% cases respectively.Conclusions: Early age, lower socio-economic class, anemia, less ANC clinic visit, higher hospital stay and primigravida observed more among study participants and these factors may play an important role in the pathogenesis of eclampsia.
ABSTRACT
Objective: The aim of this study is to determine the efficacy of methotrexate treatment for ectopic pregnancies in our settings, which will in-turn help us reduce maternal mortality and morbidity. Material and methods: This was a retrospective study of 40 cases of unruptured ectopic pregnancy treated with methotrexate in civil hospital, Ahmedabad. Clinical presentation, treatment, progress, outcome, side effects and future fertility follow-up were analyzed using database from May 2008 to June 2012. Results: The success rate of methotrexate therapy in our study was 85% (n = 35) and 15% (n = 06) required surgical intervention compared to reported success rate of 67-100% published in various studies. The mean average time of resolution of ectopic pregnancy was 32 days for a single dose and 58 days for repeat second doses. Successful fertility outcome with intrauterine pregnancy was observed in three patients. Conclusion: Methotrexate treatment of ectopic pregnancies is safe and effective with no major side effects. Intramuscular methotrexate has the advantage of tubal conservation and saves patients from surgical intervention. Our study showed single dose methotrexate to be an effective treatment option for selected patients with unruptured tubal ectopic pregnancy.